Age‐dependent decline of dopamine D1 receptors in human brain: A PET study
Identifieur interne : 003A07 ( Main/Exploration ); précédent : 003A06; suivant : 003A08Age‐dependent decline of dopamine D1 receptors in human brain: A PET study
Auteurs : Yue Wang [Canada] ; Grace L. Y. Chan [Canada] ; James E. Holden [États-Unis] ; Teresa Dobko [Canada] ; Edwin Mak [Canada] ; Michael Schulzer [Canada] ; Joseph M. Huser [Canada] ; Barry J. Snow [Canada] ; Thomas J. Ruth [Canada] ; Donald B. Calne [Canada] ; A. Jon Stoessl [Canada]Source :
- Synapse [ 0887-4476 ] ; 1998-09.
English descriptors
Abstract
Radioligand binding studies in animals have demonstrated age‐related loss of dopamine receptors in the caudate and putamen. In humans, while age‐related declines in dopamine D2 receptors have been consistently reported, the effects of ageing on D1 receptors have been controversial. We used positron emission tomography (PET) with [11C]SCH 23390 to investigate dopamine D1 receptor binding in 21 normal volunteers aged 22–74 years. We also assessed their motor function with a Modified Columbia Score (MCS) and the Purdue Pegboard Test (PPBT). D1 binding potentials were derived using a graphical analysis with a cerebellar tissue input function. Standard linear regression techniques were used to determine the age‐related rate of decline of D1 binding. We found an age‐dependent decrease of D1 receptor binding in the caudate (6.9% per decade) and putamen (7.4% per decade). There was also a significant inverse correlation between [11C]SCH 23390 binding in the occipital cortex and age (8.6% decline per decade). PPBT score also decreased with age (P = 0.007). There was a direct correlation between PPBT score and D1 binding potential. We conclude that dopamine D1 receptor density declines with age and that the effects of physiological ageing may play a role in the expression of extrapyramidal disorders in the elderly. Synapse 30:56–61, 1998. Published 1998 Wiley‐Liss, Inc.
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DOI: 10.1002/(SICI)1098-2396(199809)30:1<56::AID-SYN7>3.0.CO;2-J
Affiliations:
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Jon Stoessl</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodegenerative Disorders Centre and UBC‐TRIUMF PET Group, Vancouver Hospital, UBC site, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodegenerative Disorders Centre, UBC Hospital, UBC Site, 2221 Wesbrook Mall, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Synapse</title><title level="j" type="abbrev">Synapse</title><idno type="ISSN">0887-4476</idno><idno type="eISSN">1098-2396</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1998-09">1998-09</date><biblScope unit="volume">30</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="56">56</biblScope><biblScope unit="page" to="61">61</biblScope></imprint><idno type="ISSN">0887-4476</idno></series><idno type="istex">42F7EE8167DE4E2BA46DAA2A9DF9EC205D5C278B</idno><idno type="DOI">10.1002/(SICI)1098-2396(199809)30:1<56::AID-SYN7>3.0.CO;2-J</idno><idno type="ArticleID">SYN7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0887-4476</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>D1 receptors</term><term>ageing</term><term>dopamine</term><term>positron emission tomography (PET)</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Radioligand binding studies in animals have demonstrated age‐related loss of dopamine receptors in the caudate and putamen. In humans, while age‐related declines in dopamine D2 receptors have been consistently reported, the effects of ageing on D1 receptors have been controversial. We used positron emission tomography (PET) with [11C]SCH 23390 to investigate dopamine D1 receptor binding in 21 normal volunteers aged 22–74 years. We also assessed their motor function with a Modified Columbia Score (MCS) and the Purdue Pegboard Test (PPBT). D1 binding potentials were derived using a graphical analysis with a cerebellar tissue input function. Standard linear regression techniques were used to determine the age‐related rate of decline of D1 binding. We found an age‐dependent decrease of D1 receptor binding in the caudate (6.9% per decade) and putamen (7.4% per decade). There was also a significant inverse correlation between [11C]SCH 23390 binding in the occipital cortex and age (8.6% decline per decade). PPBT score also decreased with age (P = 0.007). There was a direct correlation between PPBT score and D1 binding potential. We conclude that dopamine D1 receptor density declines with age and that the effects of physiological ageing may play a role in the expression of extrapyramidal disorders in the elderly. Synapse 30:56–61, 1998. Published 1998 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Wisconsin</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Wang, Yue" sort="Wang, Yue" uniqKey="Wang Y" first="Yue" last="Wang">Yue Wang</name></noRegion><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name><name sortKey="Chan, Grace L Y" sort="Chan, Grace L Y" uniqKey="Chan G" first="Grace L. Y." last="Chan">Grace L. Y. Chan</name><name sortKey="Dobko, Teresa" sort="Dobko, Teresa" uniqKey="Dobko T" first="Teresa" last="Dobko">Teresa Dobko</name><name sortKey="Huser, Joseph M" sort="Huser, Joseph M" uniqKey="Huser J" first="Joseph M." last="Huser">Joseph M. Huser</name><name sortKey="Mak, Edwin" sort="Mak, Edwin" uniqKey="Mak E" first="Edwin" last="Mak">Edwin Mak</name><name sortKey="Ruth, Thomas J" sort="Ruth, Thomas J" uniqKey="Ruth T" first="Thomas J." last="Ruth">Thomas J. Ruth</name><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><name sortKey="Snow, Barry J" sort="Snow, Barry J" uniqKey="Snow B" first="Barry J." last="Snow">Barry J. Snow</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name></country><country name="États-Unis"><region name="Wisconsin"><name sortKey="Holden, James E" sort="Holden, James E" uniqKey="Holden J" first="James E." last="Holden">James E. Holden</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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